Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line
DM Harnois, FG Que, A Celli, NF LaRusso… - Hepatology, 1997 - journals.lww.com
Cholangiocarcinoma is a malignant neoplasm originating from cholangiocytes. The
mechanisms responsible for oncogenesis of cholangiocytes are unknown. Resistance to
apoptosis, especially by altered expression of B-cell lymphoma/leukemia 2 (Bcl-2) family
members, has been implicated as a mechanism contributing to malignant transformation.
Thus, our aim was to test the hypothesis that altered expression of Bcl-2 family members by
cholangiocarcinoma cells renders them resistant to apoptosis. We compared the apoptotic …
mechanisms responsible for oncogenesis of cholangiocytes are unknown. Resistance to
apoptosis, especially by altered expression of B-cell lymphoma/leukemia 2 (Bcl-2) family
members, has been implicated as a mechanism contributing to malignant transformation.
Thus, our aim was to test the hypothesis that altered expression of Bcl-2 family members by
cholangiocarcinoma cells renders them resistant to apoptosis. We compared the apoptotic …