[HTML][HTML] Mouse EP3 α, β, and γ receptor variants reduce tumor cell proliferation and tumorigenesis in vivo
IM Macias-Perez, R Zent, M Carmosino… - Journal of biological …, 2008 - ASBMB
Prostaglandin E 2, which exerts its functions by binding to four G protein-coupled receptors
(EP1-4), is implicated in tumorigenesis. Among the four E-prostanoid (EP) receptors, EP3 is
unique in that it exists as alternatively spliced variants, characterized by differences in the
cytoplasmic C-terminal tail. Although three EP3 variants, α, β, and γ, have been described in
mice, their functional significance in regulating tumorigenesis is unknown. In this study we
provide evidence that expressing murine EP3 α, β, and γ receptor variants in tumor cells …
(EP1-4), is implicated in tumorigenesis. Among the four E-prostanoid (EP) receptors, EP3 is
unique in that it exists as alternatively spliced variants, characterized by differences in the
cytoplasmic C-terminal tail. Although three EP3 variants, α, β, and γ, have been described in
mice, their functional significance in regulating tumorigenesis is unknown. In this study we
provide evidence that expressing murine EP3 α, β, and γ receptor variants in tumor cells …