[HTML][HTML] The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from …
M Oya, T Kitaguchi, R Pais, F Reimann… - Journal of Biological …, 2013 - ASBMB
Although amino acids are dietary nutrients that evoke the secretion of glucagon-like peptide
1 (GLP-1) from intestinal L cells, the precise molecular mechanism (s) by which amino acids
regulate GLP-1 secretion from intestinal L cells remains unknown. Here, we show that the G
protein-coupled receptor (GPCR), family C group 6 subtype A (GPRC6A), is involved in
amino acid-induced GLP-1 secretion from the intestinal L cell line GLUTag. Application of l-
ornithine caused an increase in intracellular Ca 2+ concentration ([Ca 2+] i) in GLUTag cells …
1 (GLP-1) from intestinal L cells, the precise molecular mechanism (s) by which amino acids
regulate GLP-1 secretion from intestinal L cells remains unknown. Here, we show that the G
protein-coupled receptor (GPCR), family C group 6 subtype A (GPRC6A), is involved in
amino acid-induced GLP-1 secretion from the intestinal L cell line GLUTag. Application of l-
ornithine caused an increase in intracellular Ca 2+ concentration ([Ca 2+] i) in GLUTag cells …