Enteroendocrine secretion of gut hormones in diabetes, obesity and after bariatric surgery
JJ Holst - Current opinion in pharmacology, 2013 - Elsevier
Highlights•Both GIP and GLP-1 levels are low in obesity, and this may contribute to, but does
not cause obesity.•Administration of glucagon-like peptide-1 (GLP-1) may restore insulin
secretion in diabetes.•Diabetes often disappears after bypass surgery while GLP-1 levels
rise dramatically.•Blocking GLP-1 receptors after bypass reestablishes diabetes.Gastric
bypass surgery is associated with a major weight loss and often causes remission in
patients with type 2 diabetes. Surgery is also associated with dramatic increases in the …
not cause obesity.•Administration of glucagon-like peptide-1 (GLP-1) may restore insulin
secretion in diabetes.•Diabetes often disappears after bypass surgery while GLP-1 levels
rise dramatically.•Blocking GLP-1 receptors after bypass reestablishes diabetes.Gastric
bypass surgery is associated with a major weight loss and often causes remission in
patients with type 2 diabetes. Surgery is also associated with dramatic increases in the …