[HTML][HTML] Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase
T Fukuda, K Kiuchi, M Takahashi - Journal of Biological Chemistry, 2002 - ASBMB
Rac activation in neuronal cells plays an important role in lamellipodia formation that is a
critical event for neuritogenesis. It is well known that the Rac activity is regulated via
activation of phosphatidylinositol 3-kinase (PI3K) by a variety of receptor tyrosine kinases.
Here we show that increased serine phosphorylation on RET receptor tyrosine kinase
following cAMP elevation promotes lamellipodia formation of neuronal cells induced by glial
cell line-derived neurotrophic factor (GDNF). We identified serine 696 in RET as a putative …
critical event for neuritogenesis. It is well known that the Rac activity is regulated via
activation of phosphatidylinositol 3-kinase (PI3K) by a variety of receptor tyrosine kinases.
Here we show that increased serine phosphorylation on RET receptor tyrosine kinase
following cAMP elevation promotes lamellipodia formation of neuronal cells induced by glial
cell line-derived neurotrophic factor (GDNF). We identified serine 696 in RET as a putative …