[HTML][HTML] Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 …

S Lépine, JC Allegood, Y Edmonds, S Milstien… - Journal of Biological …, 2011 - ASBMB
Sphingosine 1-phosphate (S1P) and ceramide have been implicated in both autophagy and
apoptosis. However, the roles of these sphingolipid metabolites in the links between these
two processes are not completely understood. Depletion of S1P phosphohydrolase-1
(SPP1), which degrades intracellular S1P, induces the unfolded protein response and
endoplasmic reticulum stress-induced autophagy (Lépine, S., Allegood, JC, Park, M., Dent,
P., Milstien, S., and Spiegel, S.(2011) Cell Death Differ. 18, 350–361). Surprisingly, however …