Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity
R Hilker, K Schweitzer, S Coburger… - Archives of …, 2005 - jamanetwork.com
Background The investigation of disease progression provides important information on the
dynamics of cell death in Parkinson disease (PD). Objective To determine the progression of
dopaminergic impairment in PD with the use of positron emission tomography (PET). Design
Longitudinal prospective cohort study with a follow-up period of 64.5±22.6 months
(mean±SD). Setting University hospital. Patients A consecutive sample of patients with PD
(N= 31; age at symptom onset, 53.6±11.3 years) with a wide range of symptom duration and …
dynamics of cell death in Parkinson disease (PD). Objective To determine the progression of
dopaminergic impairment in PD with the use of positron emission tomography (PET). Design
Longitudinal prospective cohort study with a follow-up period of 64.5±22.6 months
(mean±SD). Setting University hospital. Patients A consecutive sample of patients with PD
(N= 31; age at symptom onset, 53.6±11.3 years) with a wide range of symptom duration and …