H3 stalk-based chimeric hemagglutinin influenza virus constructs protect mice from H7N9 challenge
Journal of virology, 2014•Am Soc Microbiol
The recent outbreak of H7N9 influenza virus infections in humans in China has raised
concerns about the pandemic potential of this strain. Here, we test the efficacy of H3 stalk-
based chimeric hemagglutinin universal influenza virus vaccine constructs to protect against
H7N9 challenge in mice. Chimeric hemagglutinin constructs protected from viral challenge
in the context of different administration routes as well as with a generic oil-in-water adjuvant
similar to formulations licensed for use in humans.
concerns about the pandemic potential of this strain. Here, we test the efficacy of H3 stalk-
based chimeric hemagglutinin universal influenza virus vaccine constructs to protect against
H7N9 challenge in mice. Chimeric hemagglutinin constructs protected from viral challenge
in the context of different administration routes as well as with a generic oil-in-water adjuvant
similar to formulations licensed for use in humans.
Abstract
The recent outbreak of H7N9 influenza virus infections in humans in China has raised concerns about the pandemic potential of this strain. Here, we test the efficacy of H3 stalk-based chimeric hemagglutinin universal influenza virus vaccine constructs to protect against H7N9 challenge in mice. Chimeric hemagglutinin constructs protected from viral challenge in the context of different administration routes as well as with a generic oil-in-water adjuvant similar to formulations licensed for use in humans.
American Society for Microbiology