Activation and regulation of the inflammasomes

E Latz, TS Xiao, A Stutz - Nature Reviews Immunology, 2013 - nature.com
E Latz, TS Xiao, A Stutz
Nature Reviews Immunology, 2013nature.com
Inflammasomes are key signalling platforms that detect pathogenic microorganisms and
sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-
1β) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate
a balanced but effective inflammasome-mediated immune response, and we highlight the
similarities to another molecular signalling platform—the apoptosome—that monitors
cellular health. Extracellular regulatory mechanisms are discussed, as well as the …
Abstract
Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the similarities to another molecular signalling platform — the apoptosome — that monitors cellular health. Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy.
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