Progesterone for acute traumatic brain injury
J Ma, S Huang, S Qin, C You… - Cochrane Database of …, 2016 - cochranelibrary.com
Background Traumatic brain injury (TBI) is a leading cause of death and disability, and the
identification of effective, inexpensive and widely practicable treatments for brain injury is of
great public health importance worldwide. Progesterone is a naturally produced hormone
that has well‐defined pharmacokinetics, is widely available, inexpensive, and has steroidal,
neuroactive and neurosteroidal actions in the central nervous system. It is, therefore, a
potential candidate for treating TBI patients. However, uncertainty exists regarding the …
identification of effective, inexpensive and widely practicable treatments for brain injury is of
great public health importance worldwide. Progesterone is a naturally produced hormone
that has well‐defined pharmacokinetics, is widely available, inexpensive, and has steroidal,
neuroactive and neurosteroidal actions in the central nervous system. It is, therefore, a
potential candidate for treating TBI patients. However, uncertainty exists regarding the …
[HTML][HTML] Very early administration of progesterone for acute traumatic brain injury
DW Wright, SD Yeatts, R Silbergleit… - … England Journal of …, 2014 - Mass Medical Soc
Background Traumatic brain injury (TBI) is a major cause of death and disability worldwide.
Progesterone has been shown to improve neurologic outcome in multiple experimental
models and two early-phase trials involving patients with TBI. Methods We conducted a
double-blind, multicenter clinical trial in which patients with severe, moderate-to-severe, or
moderate acute TBI (Glasgow Coma Scale score of 4 to 12, on a scale from 3 to 15, with
lower scores indicating a lower level of consciousness) were randomly assigned to …
Progesterone has been shown to improve neurologic outcome in multiple experimental
models and two early-phase trials involving patients with TBI. Methods We conducted a
double-blind, multicenter clinical trial in which patients with severe, moderate-to-severe, or
moderate acute TBI (Glasgow Coma Scale score of 4 to 12, on a scale from 3 to 15, with
lower scores indicating a lower level of consciousness) were randomly assigned to …