Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke
D Frenkel, Z Huang, R Maron, DN Koldzic… - Journal of the …, 2005 - Elsevier
Mucosal tolerance has been used successfully to treat animal models of autoimmune
diseases and is being tested in human diseases. In this work we demonstrate the reduction
of infarct size following mucosal tolerance by myelin oligodendrocyte glycoprotein (MOG)(35–
55) peptide in mouse stroke model. Nasal MOG was most efficacious and reduced ischemic
infarct size by 70% at 24 h as well as improving behavior score. Using immunohistological
methods and IL-10−/− mice, we demonstrate the importance of IL-10-producing CD4+ T …
diseases and is being tested in human diseases. In this work we demonstrate the reduction
of infarct size following mucosal tolerance by myelin oligodendrocyte glycoprotein (MOG)(35–
55) peptide in mouse stroke model. Nasal MOG was most efficacious and reduced ischemic
infarct size by 70% at 24 h as well as improving behavior score. Using immunohistological
methods and IL-10−/− mice, we demonstrate the importance of IL-10-producing CD4+ T …