Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling
BT MacDonald, X He - Cold Spring Harbor perspectives …, 2012 - cshperspectives.cshlp.org
BT MacDonald, X He
Cold Spring Harbor perspectives in biology, 2012•cshperspectives.cshlp.orgFrizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of
cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of
receptors, including their structures and interactions with Wnt proteins, and signaling
mechanisms from receptor activation to the engagement of intracellular partners Dishevelled
and Axin, and finally to the inhibition of β-catenin phosphorylation and ensuing β-catenin
stabilization.
cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of
receptors, including their structures and interactions with Wnt proteins, and signaling
mechanisms from receptor activation to the engagement of intracellular partners Dishevelled
and Axin, and finally to the inhibition of β-catenin phosphorylation and ensuing β-catenin
stabilization.
Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of receptors, including their structures and interactions with Wnt proteins, and signaling mechanisms from receptor activation to the engagement of intracellular partners Dishevelled and Axin, and finally to the inhibition of β-catenin phosphorylation and ensuing β-catenin stabilization.
cshperspectives.cshlp.org