Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses
WO Osburn, AE Snider, BL Wells, R Latanich… - Hepatology, 2014 - journals.lww.com
The contribution of humoral immune responses to spontaneous control of hepatitis C virus
(HCV) infection remains unclear. We assessed neutralizing antibody (nAb) responses
during acute HCV infection to determine whether infection outcome is associated with the
nAb response, specifically, its timing or breadth (neutralization of multiple genotype-matched
variants). A representative genotype 1 HCV pseudoparticle (HCVpp) library, consisting of 19
genetically distinct genotype 1 HCVpp that comprise the natural variability of genotype 1 …
(HCV) infection remains unclear. We assessed neutralizing antibody (nAb) responses
during acute HCV infection to determine whether infection outcome is associated with the
nAb response, specifically, its timing or breadth (neutralization of multiple genotype-matched
variants). A representative genotype 1 HCV pseudoparticle (HCVpp) library, consisting of 19
genetically distinct genotype 1 HCVpp that comprise the natural variability of genotype 1 …