[HTML][HTML] Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure
M Watanabe, Y Horai, SM Houten, K Morimoto… - Journal of Biological …, 2011 - ASBMB
We evaluated the metabolic impact of farnesoid X receptor (FXR) activation by administering
a synthetic FXR agonist (GW4064) to mice in which obesity was induced by a high fat diet.
Administration of GW4064 accentuated body weight gain and glucose intolerance induced
by the high fat diet and led to a pronounced worsening of the changes in liver and adipose
tissue. Mechanistically, treatment with GW4064 decreased bile acid (BA) biosynthesis, BA
pool size, and energy expenditure, whereas reconstitution of the BA pool in these GW4064 …
a synthetic FXR agonist (GW4064) to mice in which obesity was induced by a high fat diet.
Administration of GW4064 accentuated body weight gain and glucose intolerance induced
by the high fat diet and led to a pronounced worsening of the changes in liver and adipose
tissue. Mechanistically, treatment with GW4064 decreased bile acid (BA) biosynthesis, BA
pool size, and energy expenditure, whereas reconstitution of the BA pool in these GW4064 …