Immune profiling by multiple gene expression analysis in patients at-risk and with type 1 diabetes
D Han, CA Leyva, D Matheson, D Mineo… - Clinical …, 2011 - Elsevier
There is a need for biomarkers to monitor the development and progression of type 1 DM.
We analyzed mRNA expression levels for granzyme B, perforin, fas ligand, TNF-α, IFN-γ,
Foxp3, IL-10, TGF-β, IL-4, IL-6, IL-17, Activation-induced cytidine deaminase (AID) and
Immunoglobulin G gamma chain (IgG) genes in peripheral blood of at-risk, new-onset and
long-term type 1 DM, and healthy controls. The majority of the genes were suppressed in
long-term type 1 DM compared to controls and new-onset patients. IFN-γ, IL-4 and IL-10 …
We analyzed mRNA expression levels for granzyme B, perforin, fas ligand, TNF-α, IFN-γ,
Foxp3, IL-10, TGF-β, IL-4, IL-6, IL-17, Activation-induced cytidine deaminase (AID) and
Immunoglobulin G gamma chain (IgG) genes in peripheral blood of at-risk, new-onset and
long-term type 1 DM, and healthy controls. The majority of the genes were suppressed in
long-term type 1 DM compared to controls and new-onset patients. IFN-γ, IL-4 and IL-10 …