[HTML][HTML] The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization
JA Cancelas, M Jansen, DA Williams - Experimental hematology, 2006 - Elsevier
Signaling downstream from the chemokine receptor CXCR4, the tyrosine kinase receptor c-
kit and β1-integrins has been shown to be crucial in the regulation of migration, homing, and
engraftment of hematopoietic stem cells and progenitors. Each of these receptors signal
through Rac-type Rho guanosine triphosphatases (GTPases). Rac GTPases play a major
role in the organization of the actin cytoskeleton and also in the control of gene expression
and the activation of proliferation and survival pathways. Here we review the specific roles of …
kit and β1-integrins has been shown to be crucial in the regulation of migration, homing, and
engraftment of hematopoietic stem cells and progenitors. Each of these receptors signal
through Rac-type Rho guanosine triphosphatases (GTPases). Rac GTPases play a major
role in the organization of the actin cytoskeleton and also in the control of gene expression
and the activation of proliferation and survival pathways. Here we review the specific roles of …