Heat shock protein-containing exosomes in mid-trimester amniotic fluids

A Asea, C Jean-Pierre, P Kaur, P Rao… - Journal of reproductive …, 2008 - Elsevier
Exosomes are multivesicular bodies formed by inverse membrane budding into the lumen of
an endocytic compartment. Fusion with the plasma membrane leads to their release into the
external milieu. The incorporation of heat shock proteins into exosomes has been
associated with immune regulatory activity. We have examined whether heat shock protein-
containing exosomes are present in mid-trimester amniotic fluid. Exosomes were isolated
from mid-trimester amniotic fluids by sequential low-speed and high-speed centrifugation …