Survivin expression correlates with apoptosis resistance after lymphocyte activation and is found preferentially in memory T cells
M Kornacker, MR Verneris, B Kornacker, C Scheffold… - Immunology …, 2001 - Elsevier
The prevention of apoptosis may be critical for immunological function. Survivin is a recently
cloned member of the inhibitor of apoptosis protein family. We analyzed survivin expression
before and after lymphocyte activation in isolated cell populations. Prior to activation,
survivin was undetectable. After activation with IL-2 and OKT-3, CD3+ cells expressed
survivin. Next, we correlated survivin expression with Fas, FasL and the amount of apoptosis
over time in culture. After activation, survivin was readily detected by day 2 and decreased …
cloned member of the inhibitor of apoptosis protein family. We analyzed survivin expression
before and after lymphocyte activation in isolated cell populations. Prior to activation,
survivin was undetectable. After activation with IL-2 and OKT-3, CD3+ cells expressed
survivin. Next, we correlated survivin expression with Fas, FasL and the amount of apoptosis
over time in culture. After activation, survivin was readily detected by day 2 and decreased …