[HTML][HTML] The thioredoxin-like protein rod-derived cone viability factor (RdCVFL) interacts with TAU and inhibits its phosphorylation in the retina
R Fridlich, F Delalande, C Jaillard, J Lu… - Molecular & Cellular …, 2009 - ASBMB
Rod-derived cone viability factor (RdCVF) is produced by the Nxnl1 gene that codes for a
second polypeptide, RdCVFL, by alternative splicing. Although the role of RdCVF in
promoting cone survival has been described, the implication of RdCVFL, a putative
thioredoxin enzyme, in the protection of photoreceptors is presently unknown. Using a
proteomics approach we identified 90 proteins interacting with RdCVFL including the
microtubule-binding protein TAU. We demonstrate that the level of phosphorylation of TAU is …
second polypeptide, RdCVFL, by alternative splicing. Although the role of RdCVF in
promoting cone survival has been described, the implication of RdCVFL, a putative
thioredoxin enzyme, in the protection of photoreceptors is presently unknown. Using a
proteomics approach we identified 90 proteins interacting with RdCVFL including the
microtubule-binding protein TAU. We demonstrate that the level of phosphorylation of TAU is …