[HTML][HTML] Increased insulin receptor substrate-1 and enhanced skeletal muscle insulin sensitivity in mice lacking CCAAT/enhancer-binding protein β
LQ Wang, J Shao, P Muhlenkamp, S Liu… - Journal of Biological …, 2000 - ASBMB
CCAAT/enhancer-binding protein β (C/EBPβ) controls gene transcription and metabolic
processes in a variety of insulin-sensitive tissues; however, its role in regulating insulin
responsiveness in vivo has not been investigated. We performed hyperinsulinemic-
euglycemic clamps in awake, non-stressed, chronically catheterized adult mice homozygous
for a deletion in the gene for C/EBPβ (C/EBPβ−/−). Fasting plasma insulin, glucose, and free
fatty acid (FFA) levels were significantly lower in C/EBPβ−/− mice compared with wild-type …
processes in a variety of insulin-sensitive tissues; however, its role in regulating insulin
responsiveness in vivo has not been investigated. We performed hyperinsulinemic-
euglycemic clamps in awake, non-stressed, chronically catheterized adult mice homozygous
for a deletion in the gene for C/EBPβ (C/EBPβ−/−). Fasting plasma insulin, glucose, and free
fatty acid (FFA) levels were significantly lower in C/EBPβ−/− mice compared with wild-type …