[HTML][HTML] CCAAT/enhancer-binding protein β and NF-κB mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to IL …
Z Zhang, JL Bryan, E DeLassus, LW Chang… - Journal of biological …, 2010 - ASBMB
A large set of chemokines is highly up-regulated in human chondrocytes in response to IL-
1β (Sandell, LJ, Xing, X., Franz, C., Davies, S., Chang, LW, and Patra, D.(2008) Osteoarthr.
Cartil. 16, 1560–1571). To investigate the mechanism of transcriptional regulation, deletion
constructs of selected chemokine gene promoters, the human CCL3 (MIP-1α) and CCL4
(MIP-1β), were transfected into human chondrocytes with or without IL-1β. The results show
that an IL-1β-responsive element is located between bp− 300 and− 140 of the CCL3 …
1β (Sandell, LJ, Xing, X., Franz, C., Davies, S., Chang, LW, and Patra, D.(2008) Osteoarthr.
Cartil. 16, 1560–1571). To investigate the mechanism of transcriptional regulation, deletion
constructs of selected chemokine gene promoters, the human CCL3 (MIP-1α) and CCL4
(MIP-1β), were transfected into human chondrocytes with or without IL-1β. The results show
that an IL-1β-responsive element is located between bp− 300 and− 140 of the CCL3 …