[HTML][HTML] Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein β (C/EBPβ) differentially regulates integrated stress response
S Dey, S Savant, BF Teske, M Hatzoglou… - Journal of Biological …, 2012 - ASBMB
Different environmental stresses induce the phosphorylation of eIF2 (eIF2∼ P), repressing
global protein synthesis coincident with preferential translation of ATF4. ATF4 is a
transcriptional activator of genes involved in metabolism and nutrient uptake, antioxidation,
and regulation of apoptosis. Because ATF4 is a common downstream target that integrates
signaling from different eIF2 kinases and their respective stress signals, the eIF2∼ P/ATF4
pathway is collectively referred to as the integrated stress response. Although eIF2∼ P …
global protein synthesis coincident with preferential translation of ATF4. ATF4 is a
transcriptional activator of genes involved in metabolism and nutrient uptake, antioxidation,
and regulation of apoptosis. Because ATF4 is a common downstream target that integrates
signaling from different eIF2 kinases and their respective stress signals, the eIF2∼ P/ATF4
pathway is collectively referred to as the integrated stress response. Although eIF2∼ P …