Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptor inverse agonist L-655,708
BJ Saab, AJB MacLean, M Kanisek… - The Journal of the …, 2010 - pubs.asahq.org
Background Memory blockade is an essential component of the anesthetic state. However,
postanesthesia memory deficits represent an undesirable and poorly understood adverse
effect. Inhibitory α5 subunit-containing γ-aminobutyric acid subtype A receptors (α5GABAA)
are known to play a critical role in memory processes and are highly sensitive to positive
modulation by anesthetics. We postulated that inhibiting the activity of α5GABAA receptors
during isoflurane anesthesia would prevent memory deficits in the early postanesthesia …
postanesthesia memory deficits represent an undesirable and poorly understood adverse
effect. Inhibitory α5 subunit-containing γ-aminobutyric acid subtype A receptors (α5GABAA)
are known to play a critical role in memory processes and are highly sensitive to positive
modulation by anesthetics. We postulated that inhibiting the activity of α5GABAA receptors
during isoflurane anesthesia would prevent memory deficits in the early postanesthesia …