Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors

VB Caraiscos, EM Elliott, KE You-Ten… - Proceedings of the …, 2004 - National Acad Sciences
VB Caraiscos, EM Elliott, KE You-Ten, VY Cheng, D Belelli, JG Newell, MF Jackson
Proceedings of the National Academy of Sciences, 2004National Acad Sciences
The principal inhibitory neurotransmitter in the mammalian brain, γ-aminobutyric acid
(GABA), is thought to regulate memory processes by activating transient inhibitory
postsynaptic currents. Here we describe a nonsynaptic, tonic form of inhibition in mouse
CA1 pyramidal neurons that is generated by a distinct subpopulation of GABA type A
receptors (GABAARs). This tonic inhibitory conductance is predominantly mediated by α5
subunit-containing GABAARs (α5GABAARs) that have different pharmacological and kinetic …
The principal inhibitory neurotransmitter in the mammalian brain, γ-aminobutyric acid (GABA), is thought to regulate memory processes by activating transient inhibitory postsynaptic currents. Here we describe a nonsynaptic, tonic form of inhibition in mouse CA1 pyramidal neurons that is generated by a distinct subpopulation of GABA type A receptors (GABAARs). This tonic inhibitory conductance is predominantly mediated by α5 subunit-containing GABAARs (α5GABAARs) that have different pharmacological and kinetic properties compared to postsynaptic receptors. GABAARs that mediate the tonic conductance are well suited to detect low, persistent, ambient concentrations of GABA in the extracellular space because they are highly sensitive to GABA and desensitize slowly. Moreover, the tonic current is highly sensitive to enhancement by amnestic drugs. Given the restricted expression of α5GABAARs to the hippocampus and the association between reduced α5GABAAR function and improved memory performance in behavioral studies, our results suggest that tonic inhibition mediated by α5GABAARs in hippocampal pyramidal neurons plays a key role in cognitive processes.
National Acad Sciences