[HTML][HTML] Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver [S]
S Satapati, NE Sunny, B Kucejova, X Fu, TT He… - Journal of lipid …, 2012 - ASBMB
The manner in which insulin resistance impinges on hepatic mitochondrial function is
complex. Although liver insulin resistance is associated with respiratory dysfunction, the
effect on fat oxidation remains controversial, and biosynthetic pathways that traverse
mitochondria are actually increased. The tricarboxylic acid (TCA) cycle is the site of terminal
fat oxidation, chief source of electrons for respiration, and a metabolic progenitor of
gluconeogenesis. Therefore, we tested whether insulin resistance promotes hepatic TCA …
complex. Although liver insulin resistance is associated with respiratory dysfunction, the
effect on fat oxidation remains controversial, and biosynthetic pathways that traverse
mitochondria are actually increased. The tricarboxylic acid (TCA) cycle is the site of terminal
fat oxidation, chief source of electrons for respiration, and a metabolic progenitor of
gluconeogenesis. Therefore, we tested whether insulin resistance promotes hepatic TCA …