[HTML][HTML] Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear …
Sphingosine kinase 1 (SK1) produces the pro-survival sphingolipid sphingosine 1-
phosphate and has been implicated in inflammation, proliferation, and angiogenesis.
Recent studies identified TRAF2 as a sphingosine 1-phosphate target, implicating SK1 in
activation of the NF-κB pathway, but the functional consequences of this connection on gene
expression are unknown. Here, we find that loss of SK1 potentiates induction of the
chemokine RANTES (regulated on activation, normal T cell expressed and secreted; also …
phosphate and has been implicated in inflammation, proliferation, and angiogenesis.
Recent studies identified TRAF2 as a sphingosine 1-phosphate target, implicating SK1 in
activation of the NF-κB pathway, but the functional consequences of this connection on gene
expression are unknown. Here, we find that loss of SK1 potentiates induction of the
chemokine RANTES (regulated on activation, normal T cell expressed and secreted; also …