[HTML][HTML] Sphingosine kinases are not required for inflammatory responses in macrophages
Sphingosine kinases (Sphks), which catalyze the formation of sphingosine 1-phosphate
(S1P) from sphingosine, have been implicated as essential intracellular messengers in
inflammatory responses. Specifically, intracellular Sphk1-derived S1P was reported to be
required for NFκB induction during inflammatory cytokine action. To examine the role of
intracellular S1P in the inflammatory response of innate immune cells, we derived murine
macrophages that lack both Sphk1 and Sphk2 (MΦ Sphk dKO). Compared with WT …
(S1P) from sphingosine, have been implicated as essential intracellular messengers in
inflammatory responses. Specifically, intracellular Sphk1-derived S1P was reported to be
required for NFκB induction during inflammatory cytokine action. To examine the role of
intracellular S1P in the inflammatory response of innate immune cells, we derived murine
macrophages that lack both Sphk1 and Sphk2 (MΦ Sphk dKO). Compared with WT …