Human hepatic stellate cell line (LX-2) exhibits characteristics of bone marrow-derived mesenchymal stem cells
A Castilho-Fernandes, DC de Almeida… - … and molecular pathology, 2011 - Elsevier
The LX-2 cell line has characteristics of hepatic stellate cells (HSCs), which are considered
pericytes of the hepatic microcirculatory system. Recent studies have suggested that HSCs
might have mesenchymal origin. We have performed an extensive characterization of the LX-
2 cells and have compared their features with those of mesenchymal cells. Our data show
that LX-2 cells have a phenotype resembling activated HSCs as well as bone marrow-
derived mesenchymal stem cells (BM-MSCs). Our immunophenotypic analysis showed that …
pericytes of the hepatic microcirculatory system. Recent studies have suggested that HSCs
might have mesenchymal origin. We have performed an extensive characterization of the LX-
2 cells and have compared their features with those of mesenchymal cells. Our data show
that LX-2 cells have a phenotype resembling activated HSCs as well as bone marrow-
derived mesenchymal stem cells (BM-MSCs). Our immunophenotypic analysis showed that …