Elevated serum levels of vascular endothelial growth factor in patients with preeclampsia

PN Baker, J Krasnow, JM Roberts, KT Yeo - Obstetrics & Gynecology, 1995 - Elsevier
OBJECTIVE: To determine whether altered levels of vascular endothelial growth factor
(VEGF) may be implicated in the pathogenesis of preeclampsia, and whether VEGF
mediates the endothelial cell activation that is involved in the pathogenesis of the clinical
syndrome. METHODS: In a cross-sectional study, maternal serum samples in late pregnancy
(at the time of clinical disease) were collected from 78 nulliparous women. These subjects
were subdivided into those with preeclampsia (n= 27), nonproteinuric pregnancy-induced …