Allergic sensitization can be induced via multiple physiologic routes in an adjuvant-dependent manner
D Dunkin, MC Berin, L Mayer - Journal of Allergy and Clinical Immunology, 2011 - Elsevier
BACKGROUND: Oral exposure to food allergens may be limited in infancy, and the initial
site of antigen exposure likely plays an important role in food allergy induction. OBJECTIVE:
To examine the impact of different routes of exposure by using milk allergens, with and
without adjuvant, on sensitization. METHODS: C3H/HeJ mice were repeatedly exposed to
the milk allergen α-lactalbumin (ALA), with or without cholera toxin (CT). Sensitization routes
used were intragastric, cutaneous, intranasal, and sublingual. Anaphylaxis severity was …
site of antigen exposure likely plays an important role in food allergy induction. OBJECTIVE:
To examine the impact of different routes of exposure by using milk allergens, with and
without adjuvant, on sensitization. METHODS: C3H/HeJ mice were repeatedly exposed to
the milk allergen α-lactalbumin (ALA), with or without cholera toxin (CT). Sensitization routes
used were intragastric, cutaneous, intranasal, and sublingual. Anaphylaxis severity was …