Carbon monoxide is a poison… to microbes! CO as a bactericidal molecule
BY Chin, LE Otterbein - Current opinion in pharmacology, 2009 - Elsevier
Inflammation and immunity result in a wide range of disease processes, including chronic
obstructive pulmonary disease, ischemia–reperfusion injury, atherosclerosis, vascular
thrombosis and sepsis. Heme oxygenase-1 (HO-1) is a key enzyme that is indispensable for
the temporal and spatial regulation of host response and, together with its essential
metabolite carbon monoxide (CO), is crucial for maintaining homeostasis, inhibition of
inflammation and the preservation of function and life. The biology of HO-1 is being …
obstructive pulmonary disease, ischemia–reperfusion injury, atherosclerosis, vascular
thrombosis and sepsis. Heme oxygenase-1 (HO-1) is a key enzyme that is indispensable for
the temporal and spatial regulation of host response and, together with its essential
metabolite carbon monoxide (CO), is crucial for maintaining homeostasis, inhibition of
inflammation and the preservation of function and life. The biology of HO-1 is being …