Heterologous human immunodeficiency virus type 1 priming-boosting immunization strategies involving replication-defective adenovirus and poxvirus vaccine vectors
DR Casimiro, AJ Bett, T Fu, ME Davies, A Tang… - Journal of …, 2004 - Am Soc Microbiol
DR Casimiro, AJ Bett, T Fu, ME Davies, A Tang, KA Wilson, M Chen, R Long, T McKelvey…
Journal of virology, 2004•Am Soc MicrobiolWe compared the human immunodeficiency virus type 1 (HIV-1)-specific cellular immune
responses elicited in nonhuman primates by HIV-1 gag-expressing replication-defective
adenovirus serotype 5 (Ad5) or poxvirus vectors, used either alone or in combination with
each other. The responses arising from a heterologous Ad5 priming-poxvirus boosting
regimen were significantly greater than those elicited by homologous regimens with the
individual vectors or by a heterologous poxvirus priming-Ad5 boosting regimen. The …
responses elicited in nonhuman primates by HIV-1 gag-expressing replication-defective
adenovirus serotype 5 (Ad5) or poxvirus vectors, used either alone or in combination with
each other. The responses arising from a heterologous Ad5 priming-poxvirus boosting
regimen were significantly greater than those elicited by homologous regimens with the
individual vectors or by a heterologous poxvirus priming-Ad5 boosting regimen. The …
Abstract
We compared the human immunodeficiency virus type 1 (HIV-1)-specific cellular immune responses elicited in nonhuman primates by HIV-1 gag-expressing replication-defective adenovirus serotype 5 (Ad5) or poxvirus vectors, used either alone or in combination with each other. The responses arising from a heterologous Ad5 priming-poxvirus boosting regimen were significantly greater than those elicited by homologous regimens with the individual vectors or by a heterologous poxvirus priming-Ad5 boosting regimen. The heterologous Ad5 priming-poxvirus boosting approach may have potential utility in humans as a means of inducing high levels of cellular immunity.
American Society for Microbiology