[HTML][HTML] Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells
MR Pan, MF Hou, HC Chang, WC Hung - Journal of Biological Chemistry, 2008 - ASBMB
Recent studies demonstrate that cyclooxygenase-2 (COX-2) expression is frequently
associated with lymph node metastasis. However, the mechanism by which COX-2
increases the invasion of cancer cells to lymph node is unclear. CCR7 is a chemokine
receptor that plays important roles in the mediation of migration of leukocytes and dendritic
cells toward lymphatic endothelial cells (LECs) that express receptor ligand CCL21. We
found that treatment of prostaglandin E 2 or ectopic expression of COX-2 in MCF-7 cells up …
associated with lymph node metastasis. However, the mechanism by which COX-2
increases the invasion of cancer cells to lymph node is unclear. CCR7 is a chemokine
receptor that plays important roles in the mediation of migration of leukocytes and dendritic
cells toward lymphatic endothelial cells (LECs) that express receptor ligand CCL21. We
found that treatment of prostaglandin E 2 or ectopic expression of COX-2 in MCF-7 cells up …