[HTML][HTML] Single administration of thrombopoietin to lethally irradiated mice prevents infectious and thrombotic events leading to mortality

MA Mouthon, MH Gaugler, A Van der Meeren… - Experimental …, 2001 - Elsevier
OBJECTIVE: A sufficiently high dose of thrombopoietin to overcome initial c-mpl–mediated
clearance stimulates hematopoietic reconstitution following myelosuppressive treatment. We
studied the efficacy of thrombopoietin on survival after supralethal total body irradiation (9
Gy) of C57BL6/J mice and the occurrence of infectious and thrombotic complications in
comparison with a bone marrow graft or prophylactic antibiotic treatment. METHODS AND
RESULTS: Administration of 0.3 μg thrombopoietin, 2 hours after irradiation, protected 62 …