Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa
S Radulovic, MR Jacobson, SR Durham… - Journal of Allergy and …, 2008 - Elsevier
BACKGROUND: Regulatory T (Treg) cells play an important role in controlling allergic
inflammation. The transcription factor Foxp3 regulates the development and function of
natural and adaptive CD4+ CD25+ Treg cells. OBJECTIVES: We sought to examine the
effect of grass pollen injection immunotherapy on the numbers of Foxp3+ CD4+ and Foxp3+
CD25+ T cells in and out of season and their expression of IL-10 in the nasal mucosa of
patients with hay fever. METHODS: Nasal biopsy specimens were obtained from untreated …
inflammation. The transcription factor Foxp3 regulates the development and function of
natural and adaptive CD4+ CD25+ Treg cells. OBJECTIVES: We sought to examine the
effect of grass pollen injection immunotherapy on the numbers of Foxp3+ CD4+ and Foxp3+
CD25+ T cells in and out of season and their expression of IL-10 in the nasal mucosa of
patients with hay fever. METHODS: Nasal biopsy specimens were obtained from untreated …