[HTML][HTML] Abnormal taste perception in mice lacking the type 3 inositol 1, 4, 5-trisphosphate receptor
C Hisatsune, K Yasumatsu… - Journal of biological …, 2007 - ASBMB
Inositol 1, 4, 5-trisphosphate receptor (IP 3 R) is one of the important calcium channels
expressed in the endoplasmic reticulum and has been shown to play crucial roles in various
physiological phenomena. Type 3 IP 3 R is expressed in taste cells, but the physiological
relevance of this receptor in taste perception in vivo is still unknown. Here, we show that
mice lacking IP 3 R3 show abnormal behavioral and electrophysiological responses to
sweet, umami, and bitter substances that trigger G-protein-coupled receptor activation. In …
expressed in the endoplasmic reticulum and has been shown to play crucial roles in various
physiological phenomena. Type 3 IP 3 R is expressed in taste cells, but the physiological
relevance of this receptor in taste perception in vivo is still unknown. Here, we show that
mice lacking IP 3 R3 show abnormal behavioral and electrophysiological responses to
sweet, umami, and bitter substances that trigger G-protein-coupled receptor activation. In …