Linking structure to function: recent lessons from inositol 1, 4, 5-trisphosphate receptor mutagenesis
DI Yule, MJ Betzenhauser, SK Joseph - Cell calcium, 2010 - Elsevier
Great insight has been gained into the structure and function of the inositol 1, 4, 5
trisphosphate receptor (InsP3R) by studies employing mutagenesis of the cDNA encoding
the receptor. Notably, early studies using this approach defined the key constituents
required for InsP3 binding in the N-terminus and the membrane spanning regions in the C-
terminal domain responsible for channel formation, targeting and function. In this article we
evaluate recent studies which have used a similar approach to investigate key residues …
trisphosphate receptor (InsP3R) by studies employing mutagenesis of the cDNA encoding
the receptor. Notably, early studies using this approach defined the key constituents
required for InsP3 binding in the N-terminus and the membrane spanning regions in the C-
terminal domain responsible for channel formation, targeting and function. In this article we
evaluate recent studies which have used a similar approach to investigate key residues …