Subcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression
PE Holtzheimer, ME Kelley, RE Gross… - Archives of general …, 2012 - jamanetwork.com
Context Deep brain stimulation (DBS) may be an effective intervention for treatment-resistant
depression (TRD), but available data are limited. Objective To assess the efficacy and safety
of subcallosal cingulate DBS in patients with TRD with either major depressive disorder
(MDD) or bipolar II disorder (BP). Design Open-label trial with a sham lead-in phase. Setting
Academic medical center. Patients Men and women aged 18 to 70 years with a moderate-to-
severe major depressive episode after at least 4 adequate antidepressant treatments. Ten …
depression (TRD), but available data are limited. Objective To assess the efficacy and safety
of subcallosal cingulate DBS in patients with TRD with either major depressive disorder
(MDD) or bipolar II disorder (BP). Design Open-label trial with a sham lead-in phase. Setting
Academic medical center. Patients Men and women aged 18 to 70 years with a moderate-to-
severe major depressive episode after at least 4 adequate antidepressant treatments. Ten …