Harnessing the platelet signaling network to produce an optimal hemostatic response
LF Brass, M Tomaiuolo… - Hematology/Oncology …, 2013 - hemonc.theclinics.com
Platelets have evolved to be the primary cellular component of the hemostatic response to
injury, replacing the nucleated thrombocytes found in most nonmammalian species. After
maturing from megakaryocyte-derived proplatelets, platelets circulate in an essentially
quiescent state for 10 days in humans, and about half of that in mice. During that time, the
quiescent state is maintained by extrinsic regulators such as nitrogen monoxide (NO) and
prostacyclin (PGI2) by the presence of healthy endothelium, which separates platelets from …
injury, replacing the nucleated thrombocytes found in most nonmammalian species. After
maturing from megakaryocyte-derived proplatelets, platelets circulate in an essentially
quiescent state for 10 days in humans, and about half of that in mice. During that time, the
quiescent state is maintained by extrinsic regulators such as nitrogen monoxide (NO) and
prostacyclin (PGI2) by the presence of healthy endothelium, which separates platelets from …