[HTML][HTML] Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly
SJ Scales, BA Hesser, ES Masuda… - Journal of Biological …, 2002 - ASBMB
The regulation of SNARE complex assembly likely plays an important role in governing the
specificity as well as the timing of membrane fusion. Here we identify a novel brain-enriched
protein, amisyn, with a tomosyn-and VAMP-like coiled-coil-forming domain that binds
specifically to syntaxin 1a and syntaxin 4 bothin vitro and in vivo, as assessed by co-
immunoprecipitation from rat brain. Amisyn is mostly cytosolic, but a fraction co-sediments
with membranes. The amisyn coil domain can form SNARE complexes of greater …
specificity as well as the timing of membrane fusion. Here we identify a novel brain-enriched
protein, amisyn, with a tomosyn-and VAMP-like coiled-coil-forming domain that binds
specifically to syntaxin 1a and syntaxin 4 bothin vitro and in vivo, as assessed by co-
immunoprecipitation from rat brain. Amisyn is mostly cytosolic, but a fraction co-sediments
with membranes. The amisyn coil domain can form SNARE complexes of greater …