Isoketals: highly reactive γ-ketoaldehydes formed from the H2-isoprostane pathway
SS Davies, V Amarnath, LJ Roberts II - Chemistry and physics of lipids, 2004 - Elsevier
Oxidation of arachidonic acid leads to the formation of highly reactive γ-ketoaldehydes now
termed isoketals. Isoketals react with proteins at a rate that far exceeds other well studied
products of lipid peroxidation such as 4-hydroxynonenal and demonstrate a remarkable
proclivity to crosslink these proteins. For these reasons, isoketals have the potential to
significantly alter protein function and contribute to disease processes. This article reviews
the chemistry of isoketal formation, of their adduction to proteins, and of their proclivity to …
termed isoketals. Isoketals react with proteins at a rate that far exceeds other well studied
products of lipid peroxidation such as 4-hydroxynonenal and demonstrate a remarkable
proclivity to crosslink these proteins. For these reasons, isoketals have the potential to
significantly alter protein function and contribute to disease processes. This article reviews
the chemistry of isoketal formation, of their adduction to proteins, and of their proclivity to …