[HTML][HTML] A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease
J Ochoa-Reparaz, DW Mielcarz, Y Wang… - Mucosal …, 2010 - Elsevier
The intestinal microbiome may have a critical roll in susceptibility or resistance to immune-
mediated diseases. Alterations of the gut microflora after oral antibiotic treatment can
regulate encephalomyelitis (EAE), an animal model for human multiple sclerosis (MS). We
now show that a zwitterionic capsular polysaccharide A (PSA) of Bacteroides fragilis can
protect against central nervous system demyelinating disease. Oral administration with
purified PSA protected mice against EAE prophylactic and therapeutically. PSA treatment …
mediated diseases. Alterations of the gut microflora after oral antibiotic treatment can
regulate encephalomyelitis (EAE), an animal model for human multiple sclerosis (MS). We
now show that a zwitterionic capsular polysaccharide A (PSA) of Bacteroides fragilis can
protect against central nervous system demyelinating disease. Oral administration with
purified PSA protected mice against EAE prophylactic and therapeutically. PSA treatment …