Isolations of a cartilage factor that inhibits tumor neovascularization

R Langer, H Brem, K Falterman, M Klein, J Folkman - Science, 1976 - science.org
R Langer, H Brem, K Falterman, M Klein, J Folkman
Science, 1976science.org
A cartilage fraction isolated by guanidine extraction and purified by affinity chromatography
inhibits tumor-induced vascular proliferation and consequently restricts tumor growth. This
fraction contains several different proteins; the major one has a molecular weight of about
16,000. The fraction strongly inhibits protease activity.
A cartilage fraction isolated by guanidine extraction and purified by affinity chromatography inhibits tumor-induced vascular proliferation and consequently restricts tumor growth. This fraction contains several different proteins; the major one has a molecular weight of about 16,000. The fraction strongly inhibits protease activity.
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