[HTML][HTML] Predicting biomarkers for ovarian cancer using gene-expression microarrays

TR Adib, S Henderson, C Perrett, D Hewitt… - British journal of …, 2004 - nature.com
TR Adib, S Henderson, C Perrett, D Hewitt, D Bourmpoulia, J Ledermann, C Boshoff
British journal of cancer, 2004nature.com
Ovarian cancer has the highest mortality rate of gynaecological cancers. This is partly due to
the lack of effective screening markers. Here, we used oligonucleotide microarrays
complementary to∼ 12 000 genes to establish a gene-expression microarray (GEM) profile
for normal ovarian tissue, as compared to stage III ovarian serous adenocarcinoma and
omental metastases from the same individuals. We found that the GEM profiles of the
primary and secondary tumours from the same individuals were essentially alike, reflecting …
Abstract
Ovarian cancer has the highest mortality rate of gynaecological cancers. This is partly due to the lack of effective screening markers. Here, we used oligonucleotide microarrays complementary to∼ 12 000 genes to establish a gene-expression microarray (GEM) profile for normal ovarian tissue, as compared to stage III ovarian serous adenocarcinoma and omental metastases from the same individuals. We found that the GEM profiles of the primary and secondary tumours from the same individuals were essentially alike, reflecting the fact that these tumours had already metastasised and acquired the metastatic phenotype. We have identified a novel biomarker, mammaglobin-2 (MGB2), which is highly expressed specific to ovarian cancer. MGB2, in combination with other putative markers identified here, could have the potential for screening.
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