[HTML][HTML] Shape analysis of subcortical nuclei in Huntington's disease, global versus local atrophy—Results from the TRACK-HD study
SJA van den Bogaard, EM Dumas, L Ferrarini… - Journal of the …, 2011 - Elsevier
Huntington's disease (HD) is characterized by brain atrophy. Localized atrophy of a specific
structure could potentially be a more sensitive biomarker reflecting neuropathologic
changes rather than global volume variation. We examined 90 TRACK-HD participants of
which 30 were premanifest HD, 30 were manifest HD and 30 were controls. Using FMRIB's
Integrated Registration and Segmentation Tool, segmentations were obtained for the
pallidum, caudate nucleus, putamen, thalamus, accumbens nucleus, amygdala, and …
structure could potentially be a more sensitive biomarker reflecting neuropathologic
changes rather than global volume variation. We examined 90 TRACK-HD participants of
which 30 were premanifest HD, 30 were manifest HD and 30 were controls. Using FMRIB's
Integrated Registration and Segmentation Tool, segmentations were obtained for the
pallidum, caudate nucleus, putamen, thalamus, accumbens nucleus, amygdala, and …