Fibronectin is a component of subendothelial matrices and abundant in plasma. A role of
fibronectin in thrombogenesis has been suspected for three decades. Soluble fibronectin is
assembled by adherent fibroblasts and platelets and thus converted to an insoluble form that
mediates cell adhesion. Recently, in vivo studies using intravital videomicroscopy revealed
that plasma fibronectin is important for stabilization of platelet aggregates after vascular
injury. This review goes over roles of fibronectin in platelet functions with a focus on …