2.2. Clinically effective doses 2.3. Absorption and metabolism 2.4. Metabolism in rats 2.5. Plasma concentrations 2.6. Brain concentrations 2.7. Adipose tissue concentrations 2.8. Other tissues 3. Clinical observations 3.1. Weight loss 3.2. Behavior modification 3.3. Hunger ratings 3.4. Diet selection 4. Behavioral findings in animals 4.1. Acute anorexia 4.1. 1. Deprivation paradigms 4.1. 2. Enantiomers and metabolites of fenfluramine 4.1. 3. Acute tests without food deprivation 4.1. 4. Intracerebral application 4.2. Behavioral specificity 4.2. 1. Water intake after fenfluramine 4.2. 2. Sleep and arousal 4.2. 3. Learning and memory 4.2. 4. General activity 4.3. Tolerance, cross-tolerance and set point 4.3. 1. Tolerance to anorexia in acute feeding tests 4.3. 2. Prior weight loss and anorexia 4.3. 3. The" set point" argument 4.3. 4. Cross tolerance 4.4. Free feeding and tolerance to weight loss/anorexia 4.4. 1. Meal patterns

4.4. 2. Weight loss 4.5. Obese rodent models 4.6. Diet selection and fenfluramine in rats 4.7. Nutrients, pre-loads and fenfluramine action 4.8. Conditioned taste aversion 4.9. Discriminative stimulus properties 5. Peripheral actions 5.1. Gastric emptying and intestinal motility 5.1. 1. Inhibition of gastric emptying 5.1. 2. Emptying and food intake---rodents 5.1. 3. Emptying and food intake---primates 5.2. Mechanism of gastric inhibition 5.3. Sham feeding