Treating bulimia with desipramine: A double-blind, placebo-controlled study
PL Hughes, LA Wells, CJ Cunningham… - Archives of General …, 1986 - jamanetwork.com
• A controlled study in patients with bulimia demonstrated a significant benefit from
desipramine hydrochloride treatment (91% decrease in binge frequency) in contrast to the
results from a placebo (19% increase in frequency). When patients originally taking the
placebo crossed over to desipramine therapy, their frequency of binges decreased 84%, so
that the overall improvement was 87% fewer binges. Global clinical status improved 3.5
scales, Zung depression scores improved 8.0 points, and a bulimia symptom scale improved …
desipramine hydrochloride treatment (91% decrease in binge frequency) in contrast to the
results from a placebo (19% increase in frequency). When patients originally taking the
placebo crossed over to desipramine therapy, their frequency of binges decreased 84%, so
that the overall improvement was 87% fewer binges. Global clinical status improved 3.5
scales, Zung depression scores improved 8.0 points, and a bulimia symptom scale improved …