Microvascular density of the human paraventricular nucleus decreases with aging but not hypertension

WB Abernethy, MA Bell, M Morris, DM Moody - Experimental neurology, 1993 - Elsevier
WB Abernethy, MA Bell, M Morris, DM Moody
Experimental neurology, 1993Elsevier
Microvascular density was determined in the supraoptic nuclei (SON) and paraventricular
nuclei (PVN) of fixed brain tissue from 19 human subjects ranging in age from 30 to 85
years. Eight of these patients had hypertension. No sex-or hypertension-related differences
in microvascular density were found in either the SON or PVN. However, capillary density
decreased in the PVN with aging. These results indicate a differential pattern of
microvascular loss in the human hypothalamus with aging.
Abstract
Microvascular density was determined in the supraoptic nuclei (SON) and paraventricular nuclei (PVN) of fixed brain tissue from 19 human subjects ranging in age from 30 to 85 years. Eight of these patients had hypertension. No sex- or hypertension-related differences in microvascular density were found in either the SON or PVN. However, capillary density decreased in the PVN with aging. These results indicate a differential pattern of microvascular loss in the human hypothalamus with aging.
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