Detection of human immunodeficiency virus–induced inflammation and oxidative stress in lenticular nuclei with magnetic resonance spectroscopy despite …

AC Roc, BM Ances, S Chawla… - Archives of …, 2007 - jamanetwork.com
Background Single-voxel magnetic resonance spectroscopy measurements ofN-acetyl
aspartate, choline, and creatine (Cr) are affected in patients with human immunodeficiency
virus (HIV) and neurocognitive impairment. However, these metabolic markers are often
normalized in affected central nervous system regions, such as the lenticular nuclei, after
initiation of highly active antiretroviral therapy (HAART). Objective To examine whether
lactate (Lac), a marker of inflammation and anaerobic glycolysis, and lipid, an indicator of …